Methylamine → HCID 7406921, compound

HRID 1406509Notes

Reaction equation

HRID 1406509 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:20])[C:10]2[CH:15]=[CH:14][C:13](F)=[C:12]([N+:17]([O-:19])=[O:18])[CH:11]=2)=[CH:4][CH:3]=1.[CH3:21][NH2:22]>C(OCC)(=O)C>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:20])[C:10]2[CH:15]=[CH:14][C:13]([NH:22][CH3:21])=[C:12]([N+:17]([O-:19])=[O:18])[CH:11]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 3651415HCID 3651415, compound

Product 1

HCID 7406921HCID 7406921, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Conditions

Temperature
60 °C

Procedure

A mixture of N-(4-bromo-phenyl)-4-fluoro-3-nitro-benzamide (1.5 g, 4.4 mmol) and 40 mL liquid methyl amine was stirred for 20 h at 60° C. The mixture was cooled to −78° C., diluted with ethyl acetate and filtered with celite and silica gel. The filtrate was concentrated i.vac.

Workup

  1. temperatureThe mixture was cooled to −78° C.
  2. filtrationfiltered with celite and silica gel
  3. concentrationThe filtrate was concentrated i.vac

Sources & evidence

ORD record
ord-0a73107cc7f54b6b8d163ed303ace639
Source dataset
uspto-grants-2014_12
Patent number
US08916599B2

Reaction notes

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