反应详情

温度

60 °C

A mixture of N-(4-bromo-phenyl)-4-fluoro-3-nitro-benzamide (1.5 g, 4.4 mmol) and 40 mL liquid methyl amine was stirred for 20 h at 60° C. The mixture was cooled to −78° C., diluted with ethyl acetate and filtered with celite and silica gel. The filtrate was concentrated i.vac.

1. temperatureThe mixture was cooled to −78° C.
2. filtrationfiltered with celite and silica gel
3. concentrationThe filtrate was concentrated i.vac