Tetrahydrofuran → 2-(4-Chloro-phenyl)-3-cyclopentyl-propionic acid

HRID 140729Notes

Reaction equation

HRID 140729 reaction equation
[CH3:27][N:28]1[CH2:29][CH2:30][CH2:31][N:32]([CH3:33])[C:34]1=[O:35].[CH3:41][N:42]1[CH2:43][CH2:44][CH2:45][N:46]([CH3:47])[C:48]1=[O:49].[CH:1]([N-:2][CH:3]([CH3:4])[CH3:5])([CH3:6])[CH3:7].[Cl:9][c:10]1[cH:11][cH:12][c:13]([CH2:16][C:17](=[O:18])[OH:19])[cH:14][cH:15]1.[I:20][CH2:21][CH:22]1[CH2:23][CH2:24][CH2:25][CH2:26]1.[Li+:8].[O:36]1[CH2:37][CH2:38][CH2:39][CH2:40]1>>[Cl:9][c:10]1[cH:11][cH:12][c:13]([CH:16]([C:17](=[O:18])[OH:19])[CH2:21][CH:22]2[CH2:23][CH2:24][CH2:25][CH2:26]2)[cH:14][cH:15]1

Participants

7

Reactant 6

HCID 8028TetrahydrofuranHCID 15880(4-Chlorophenyl)acetic acidHCID 28486Lithium ionHCID 816462(1H)-Pyrimidinone, tetrahydro-1,3-dimethyl-2×HCID 2762531(Iodomethyl)cyclopentaneHCID 5062348Diisopropylamide

Product 1

HCID 223152972-(4-Chloro-phenyl)-3-cyclopentyl-propionic acid

Sources & evidence

ORD record
ord-e8484144199c4b759b0e0f0e8e5ff02b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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