反应详情

温度

60 °C

Ethyl 2-methyl-1H-imidazole-4-carboxylate (3.24 mmol, 500 mg) and potassium carbonate (32.4 mmol, 4482 mg) were dissolved in DMF (10 ml). (R)-(+)-propylene oxide (48.6 mmol, 3.41 ml) was added and the resulting mixture was stirred at 60° C. for 5.5 h. More (R)-(+)-propylene oxide (1.5 ml) was added and the heating continued for another hour. The mixture was evaporated and the residue was purified by flash chromatography. 525 mg of the title compound was obtained. 1H-NMR (400 MHz, DMSO-d6): δ 1.06 (d, 3H), 1.25 (t, 3H), 2.30 (s, 3H), 3.68-4.00 (m, 3H), 4.18 (q, 2H), 4.95 (d, 1H), 7.73 (s, 1H).

1. waitthe heating continued for another hour
2. customThe mixture was evaporated
3. customthe residue was purified by flash chromatography