Methylamine → HCID 136377095, compound

HRID 1409585Notes

Reaction equation

HRID 1409585 reaction equation
C[O:2][C:3]([C:5]1[N:6]=[C:7]([CH2:13][C:14]2[CH:19]=[C:18]([C:20]([F:23])([F:22])[F:21])[CH:17]=[CH:16][C:15]=2[Br:24])[NH:8][C:9](=[O:12])[C:10]=1[OH:11])=O.[CH3:25][NH2:26]>C1COCC1>[CH3:25][NH:26][C:3]([C:5]1[N:6]=[C:7]([CH2:13][C:14]2[CH:19]=[C:18]([C:20]([F:21])([F:22])[F:23])[CH:17]=[CH:16][C:15]=2[Br:24])[NH:8][C:9](=[O:12])[C:10]=1[OH:11])=[O:2]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 136377096HCID 136377096, compound

Product 1

HCID 136377095HCID 136377095, compoundYield 53%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The compound was prepared according to the same procedure as in Example 21 using 2-(2-bromo-5-trifluoromethyl-benzyl)-5-hydroxy-6-oxo-1,6-dihydro-pyrimidine-4-carboxylic acid methyl ester (0.080 g; 0.197 mmol) and 2M methylamine solution in THF (1 ml). This provided the title product as an off-white solid (0.043 g; 53%). LCMS: m/z=427 (MH+).

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-8d6edd145af34fe2858946a075ac467f
Source dataset
uspto-grants-2014_12
Patent number
US08921388B2

Reaction notes

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