Hydrochloric Acid → HCID 71112568, compound

HRID 1409727Notes

Reaction equation

HRID 1409727 reaction equation
Cl[C:2]1[N:3]=[CH:4][C:5]([C:8]([O:10]C)=[O:9])=[N:6][CH:7]=1.C([O-])([O-])=O.[K+].[K+].[CH3:18][C:19]1[N:23]=[CH:22][NH:21][N:20]=1.Cl>CN(C)C=O>[CH3:18][C:19]1[N:23]=[CH:22][N:21]([C:2]2[N:3]=[CH:4][C:5]([C:8]([OH:10])=[O:9])=[N:6][CH:7]=2)[N:20]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 11430Potassium CarbonateHCID 406081Methyl 5-chloropyrazine-2-carboxylateHCID 178433329HCID 178433329, compound

Product 1

HCID 71112568HCID 71112568, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of methyl 5-chloropyrazine-2-carboxylate (0.75 g), K2CO3 (1.8 g) and 3-methyl-1H-1,2,4-triazole (1.2 g) in N,N-dimethylformamide (6 mL) is heated to 100° C. overnight. Analysis of the crude mixture by LCMS shows saponified product. The product is acidified with 1N HCl and the precipitate is filtered and washed with water and diethyl ether to afford the title compound. LC (method 20): tR=1.21 min; Mass spectrum (APCI): m/z=206 [M+H]+.

Workup

  1. filtrationthe precipitate is filtered
  2. washwashed with water and diethyl ether

Sources & evidence

ORD record
ord-84e97c23f4ba408688cb3b773c80f3c8
Source dataset
uspto-grants-2014_12
Patent number
US08921398B2

Reaction notes

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