Hydrochloric Acid → HCID 71093725, Verbindung

HRID 1409735Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1409735
Cl[C:2]1[N:7]=[CH:6][C:5]([C:8]([OH:10])=[O:9])=[CH:4][N:3]=1.[CH3:11][C:12]1[NH:13][CH:14]=[CH:15][N:16]=1.C(=O)([O-])[O-].[K+].[K+].Cl>CN(C)C=O>[CH3:11][C:12]1[N:13]([C:2]2[N:7]=[CH:6][C:5]([C:8]([OH:10])=[O:9])=[CH:4][N:3]=2)[CH:14]=[CH:15][N:16]=1

Komponenten

6

Edukt 4

HCID 313Hydrochloric Acid2×HCID 11430Potassium CarbonateHCID 127492-MethylimidazoleHCID 110949062-Chloropyrimidine-5-carboxylic acid

Produkt 1

HCID 71093725HCID 71093725, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

2-Chloropyrimidine-5-carboxylic acid (0.75 g), 2-methylimidazole (0.117 g) and potassium carbonate (1.96 g) in 3.75 mL of N,N-dimethylformamide are heated in microwave at 50° C. for 30 min, then cooled to room temperature and acidified with 3 mL of 1 N HCl, followed by addition of conc. HCl to pH 2. The precipitate is filtered, washed with minimum amount of water, diethyl ether and dried in vacuo to afford the title compound. LC (method 20): tR=0.48 min; Mass spectrum (APCI): m/z=205 [M+H]+.

Aufarbeitung

  1. filtrationThe precipitate is filtered
  2. washwashed with minimum amount of water, diethyl ether
  3. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-d07a461e37c2459d9b541836918c592e
Quelldatensatz
uspto-grants-2014_12
Patentnummer
US08921398B2

Notizen zur Reaktion

Wird geladen…