Hydrochloric Acid → HCID 71093725, compound

HRID 1409735Notes

Reaction equation

HRID 1409735 reaction equation
Cl[C:2]1[N:7]=[CH:6][C:5]([C:8]([OH:10])=[O:9])=[CH:4][N:3]=1.[CH3:11][C:12]1[NH:13][CH:14]=[CH:15][N:16]=1.C(=O)([O-])[O-].[K+].[K+].Cl>CN(C)C=O>[CH3:11][C:12]1[N:13]([C:2]2[N:7]=[CH:6][C:5]([C:8]([OH:10])=[O:9])=[CH:4][N:3]=2)[CH:14]=[CH:15][N:16]=1

Participants

6

Reactant 4

HCID 313Hydrochloric Acid2×HCID 11430Potassium CarbonateHCID 127492-MethylimidazoleHCID 110949062-Chloropyrimidine-5-carboxylic acid

Product 1

HCID 71093725HCID 71093725, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

2-Chloropyrimidine-5-carboxylic acid (0.75 g), 2-methylimidazole (0.117 g) and potassium carbonate (1.96 g) in 3.75 mL of N,N-dimethylformamide are heated in microwave at 50° C. for 30 min, then cooled to room temperature and acidified with 3 mL of 1 N HCl, followed by addition of conc. HCl to pH 2. The precipitate is filtered, washed with minimum amount of water, diethyl ether and dried in vacuo to afford the title compound. LC (method 20): tR=0.48 min; Mass spectrum (APCI): m/z=205 [M+H]+.

Workup

  1. filtrationThe precipitate is filtered
  2. washwashed with minimum amount of water, diethyl ether
  3. customdried in vacuo

Sources & evidence

ORD record
ord-d07a461e37c2459d9b541836918c592e
Source dataset
uspto-grants-2014_12
Patent number
US08921398B2

Reaction notes

Loading…