反应详情

To a solution of (S)-tert-butyl 2-(6-bromo-5-fluoro-1H-benzo[d]imidazol-2-yl)pyrrolidine-1-carboxylate (2.5 g, 6.4 mol) in THF (32 mL) was added sodium hydride (0.27 g, 6.8 mmol) and stirring was continued for 30 minutes. 2-(Trimethylsilyl)-ethoxymethyl chloride (1.2 mL, 6.8 mmol) was added and stirring was continued for 30 minutes. Water was added to quench the reaction. The mixture was diluted with EtOAc, washed with 1N HCl, H2O, and brine, dried (Na2SO4), filtered and concentrated to an oil. The oil was purified by flash chromatography (0-30% EtOAc/hexane) to give the title compound (2.9 g, 5.7 mmol, 89%).

1. stirringstirring
2. waitwas continued for 30 minutes
3. customto quench
4. customthe reaction
5. washwashed with 1N HCl, H2O, and brine
6. dry with materialdried (Na2SO4)
7. filtrationfiltered
8. concentrationconcentrated to an oil
9. customThe oil was purified by flash chromatography (0-30% EtOAc/hexane)