Water → HCID 21483905, compound

HRID 1415206Notes

Reaction equation

HRID 1415206 reaction equation
[CH:1]1([CH:6]2[CH2:15][CH2:14][C:13]3[C:8](=[C:9]([Cl:18])[C:10]([Cl:17])=[C:11]([OH:16])[CH:12]=3)[C:7]2=[O:19])[CH2:5][CH2:4][CH2:3][CH2:2]1.C(=O)([O-])[O-].[K+].[K+].Cl[CH2:27][C:28]#[N:29].O>CN(C=O)C>[CH:1]1([CH:6]2[CH2:15][CH2:14][C:13]3[C:8](=[C:9]([Cl:18])[C:10]([Cl:17])=[C:11]([O:16][CH2:27][C:28]#[N:29])[CH:12]=3)[C:7]2=[O:19])[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

6

Reactant 4

HCID 962WaterHCID 7856ChloroacetonitrileHCID 11430Potassium CarbonateHCID 21483899HCID 21483899, compound

Product 1

HCID 21483905HCID 21483905, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A stirred mixture of 2-cyclopentyl-6-hydroxy-7,8-dichloro-1-tetralone (2.9 g., 0.1 mole), potassium carbonate (15.2 g., 0.11 mole) and chloroacetonitrile (7.5 g., 0.10 mole) in DMF (100 ml.) is heated at 55°-60° C. for two hours and poured into water. The 2-cyclopentyl-6-cyanomethoxy-7,8-dichloro-1-tetralone that separates is collected and dried.

Workup

  1. temperatureis heated at 55°-60° C. for two hours
  2. customThe 2-cyclopentyl-6-cyanomethoxy-7,8-dichloro-1-tetralone that separates is collected
  3. customdried

Sources & evidence

ORD record
ord-79847d5f036d495a89281729f831d7bf
Source dataset
uspto-grants-1977_01
Patent number
US04003927

Reaction notes

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