Hydrochloric Acid → HCID 131721276, compound

HRID 1415677Notes

Reaction equation

HRID 1415677 reaction equation
N[N:2]1[CH2:7][CH2:6][N:5]([CH2:8][C:9]([OH:11])=O)[CH2:4][CH2:3]1.[NH2:12][C:13]1[CH:14]=[C:15]([CH:25]=[CH:26][CH:27]=1)[C:16]([NH:18][CH2:19][CH2:20][C:21]([O:23][CH3:24])=[O:22])=[O:17].[ClH:28].C[N:30]1[CH2:35]COCC1.C[N:37](C=O)C>>[ClH:28].[ClH:28].[C:35]([N:2]1[CH2:3][CH2:4][N:5]([CH2:8][C:9]([NH:12][C:13]2[CH:14]=[C:15]([CH:25]=[CH:26][CH:27]=2)[C:16]([NH:18][CH2:19][CH2:20][C:21]([O:23][CH3:24])=[O:22])=[O:17])=[O:11])[CH2:6][CH2:7]1)(=[NH:30])[NH2:37]

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 6228DimethylformamideHCID 79724-MethylmorpholineHCID 43665861HCID 43665861, compoundHCID 54020317HCID 54020317, compound

Product 1

HCID 131721276HCID 131721276, compound

Procedure

A mixture of 1.86 g of 4-aminopiperazin-1-ylacetic acid, 2.22 g of methyl 3-(3-aminobenzamido)propionate, 1.92 g of DAPECI hydrochloride, 1.01 g of N-methylmorpholine and 70 ml of DMF is stirred for 16 hours at 20°. It is evaporated and the residue is worked up with ethyl acetate/5% NaHCO3 solution to give methyl 3-(3-(4-amidinopiperazin-1-ylacetamido)benzamido)propionate. Dihydrochloride m.p. 222°.

Workup

  1. customIt is evaporated

Sources & evidence

ORD record
ord-b8b22faa8f1947c397efc2762aa5c7df
Source dataset
uspto-grants-1999_06
Patent number
US05908843

Reaction notes

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