Triethylamine → HCID 10589770, compound
Reaction equation
Cl[C:2]([O:4][CH2:5][CH2:6][Br:7])=[O:3].Cl.[Cl:9][CH2:10][CH2:11][NH:12][CH2:13][CH2:14][Cl:15].C(N(CC)CC)C>ClCCl>[Br:7][CH2:6][CH2:5][O:4][C:2]([N:12]([CH2:13][CH2:14][Cl:15])[CH2:11][CH2:10][Cl:9])=[O:3]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 7.5 °C
Procedure
2-Bromoethyl chloroformate (5.6 mL, 50 mmol) was added to a stirred suspension of bis(2-chloroethyl)amine hydrochloride (9.8 g, 55 mmol) in 250 mL of dry dichloromethane at 0-5° C. under argon over 2 min followed by 28 mL (200 mmol) of triethylamine over 20 min. The mixture was stirred at 5-10° C. for 3 h and at room temperature for 18 h, then suction filtered. The filtrate was concentrated in vacuo.
Workup
- filtrationsuction filtered
- concentrationThe filtrate was concentrated in vacuo
Sources & evidence
- ORD record
- ord-9ce240f3a9db44a29c86bba64536244e
- Source dataset
- uspto-grants-1999_06
- Patent number
- US05908919
Reaction notes
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