Isoamylamine → HCID 178446282, compound

HRID 1416165Notes

Reaction equation

HRID 1416165 reaction equation
[NH2:1][C:2]1[N:7]=[C:6](Cl)[C:5]([N+:9]([O-:11])=[O:10])=[C:4]([OH:12])[N:3]=1.[CH3:13][CH:14]([CH3:18])[CH2:15][CH2:16][NH2:17].C(N(CC)CC)C>C(O)C>[NH2:1][C:2]1[N:7]=[C:6]([NH:17][CH2:16][CH2:15][CH:14]([CH3:18])[CH3:13])[C:5]([N+:9]([O-:11])=[O:10])=[C:4]([OH:12])[N:3]=1

Participants

5

Reactant 3

HCID 7894IsoamylamineHCID 8471TriethylamineHCID 178418667HCID 178418667, compound

Product 1

HCID 178446282HCID 178446282, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2-Amino-4-chloro-6-hydroxy-5-nitropyrimidine (4 g), 3-methylbutylamine (1.8 g) and triethylamine (6 ml) were heated at reflux for 5 h then left stirring overnight at room temperature in ethanol. The precipitate was filtered and washed with water and air dried to yield the title compound as a yellow solid.

Workup

  1. temperatureat reflux for 5 h
  2. waitthen left
  3. filtrationThe precipitate was filtered
  4. washwashed with water and air
  5. customdried

Sources & evidence

ORD record
ord-05df86ae2c654bfb99b5cb8b89a3d49b
Source dataset
uspto-grants-1999_06
Patent number
US05912252

Reaction notes

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