Dimethylformamide → HCID 10105410, compound

HRID 1416892Notes

Reaction equation

HRID 1416892 reaction equation
[CH3:1][O:2][C:3]([N:5]1[CH2:10][CH2:9][CH:8]([CH2:11][CH2:12][C:13]([OH:15])=O)[CH2:7][CH2:6]1)=[O:4].CN(C)C=O.C(Cl)(=O)C([Cl:24])=O>ClCCl>[CH3:1][O:2][C:3]([N:5]1[CH2:10][CH2:9][CH:8]([CH2:11][CH2:12][C:13]([Cl:24])=[O:15])[CH2:7][CH2:6]1)=[O:4]

Participants

5

Reactant 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 102627174-Piperidinepropanoic acid, 1-(methoxycarbonyl)-

Product 1

HCID 10105410HCID 10105410, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 49.5 gm (0.23 mol) of the compound of step c), in dichloromethane, was added 0.25 mL of dimethylformamide and 21 mL of oxalyl chloride (0.25 mol). After gas evolution subsided, formation of the title compound was complete. The resulting solution was used directly into the next step.

Sources & evidence

ORD record
ord-a65f946bc718464eae238f468a6c0acb
Source dataset
uspto-grants-1999_06
Patent number
US05916902

Reaction notes

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