Acetic Acid → HCID 54502293, compound

73 mg of oxalyl chloride was added, with ice-cooling, to a solution of 92 mg of 1-methylcarbazole-3-carboxylic acid, as obtained in Example 27, in 5 ml of methylene chloride. One drop of N,N-dimethylformamide was then added to the reaction mixture, which was next warmed to room temperature, stirred for 2 hours, and then concentrated by evaporation under reduced pressure. 10 ml of diethyl ether and an excess of a solution of diazomethane in diethyl ether were added to the residue thus obtained, and the reaction mixture was stirred for one night at room temperature. Acetic acid and then a saturated aqueous solution of sodium hydrogencarbonate were added to the reaction mixture. The aqueous layer was extracted with ethyl acetate, and the organic extract was washed with water, dried over anhydrous magnesium sulfate and concentrated by evaporation under reduced pressure. The resulting residue was subjected to column chromatography using 2 g of silica gel with a 1:1 v/v mixture of hexane and ethyl acetate as the eluent. Subsequently, 6 mg of silver oxide was added to a solution of the eluted residue in 5 ml of methanol. The reaction mixture was refluxed for 5 hours, filtered to remove inorganic materials, and concentrated by evaporation under reduced pressure. The resulting residue was subjected to column chromatography using 2 g of silica gel with a 2:1 v/v mixture of hexane and ethyl acetate as the eluent, to yield 90 mg of the title compound as an oil.

1. concentrationconcentrated by evaporation under reduced pressure
2. addition10 ml of diethyl ether and an excess of a solution of diazomethane in diethyl ether were added to the residue
3. customthus obtained
4. stirringthe reaction mixture was stirred for one night at room temperature
5. extractionThe aqueous layer was extracted with ethyl acetate
6. extractionthe organic extract
7. washwas washed with water
8. dry with materialdried over anhydrous magnesium sulfate
9. concentrationconcentrated by evaporation under reduced pressure
10. additionwith a 1:1 v/v mixture of hexane and ethyl acetate as the eluent
11. additionSubsequently, 6 mg of silver oxide was added to a solution of the eluted residue in 5 ml of methanol
12. temperatureThe reaction mixture was refluxed for 5 hours
13. filtrationfiltered
14. customto remove inorganic materials
15. concentrationconcentrated by evaporation under reduced pressure
16. additionwith a 2:1 v/v mixture of hexane and ethyl acetate as the eluent

ORD record

ord-8598ccd3af05463ba7ddae0d79b562d1

Source dataset

uspto-grants-1999_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05877199