反应详情

To a solution of Compound (30a) (33 mg, 0.08 mmol) in 3.0 ml of 1-propanol was added 6 mg of pyridinium p-toluenesulfonate, and the mixture stirred at room temperature for one hour. To the reaction was added 20 ml of ethyl acetate. The mixture was washed with saturated brine, and dried over anhydrous sodium sulfate. After concentration under reduced pressure, the residue was purified by a column chromatography (Merck, Lobar column, size A; ethyl acetate), and by crystallization from ethyl acetate to give 22 mg (60%) of Compound (30c).

1. washThe mixture was washed with saturated brine
2. dry with materialdried over anhydrous sodium sulfate
3. concentrationAfter concentration under reduced pressure
4. customthe residue was purified by a column chromatography (Merck, Lobar column, size A
5. customethyl acetate), and by crystallization from ethyl acetate