反应详情

To a solution of Compound (45a) (50 mg, 0.087 mmol) in 5 ml of dry dichloromethane were added 30 μl (0.28 mmol) of anisole and 35 μl (0.45 mmol) of trifluoroacetic acid, and the mixture stirred for 3 hours at room temperature. Under ice-cooling, to the reaction mixture was added an aqueous saturated sodium hydrogen carbonate solution, followed by extraction with ethyl acetate. The extract was washed with water and an aqueous saturated sodium hydrogen carbonate solution, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to give 30 mg (73%) of the crude Compound (46a) as a powdery material.

1. temperatureUnder ice-cooling, to the reaction mixture
2. extractionfollowed by extraction with ethyl acetate
3. washThe extract was washed with water
4. dry with materialan aqueous saturated sodium hydrogen carbonate solution, dried over anhydrous magnesium sulfate
5. concentrationconcentrated under reduced pressure