3-(Dimethylamino)phenol → HCID 67568574, compound

HRID 1418599Notes

Reaction equation

HRID 1418599 reaction equation
[F:1][C:2]1[CH:3]=[C:4](/[CH:19]=[C:20](\[CH3:24])/[C:21]([OH:23])=[O:22])[CH:5]=[C:6]([F:18])[C:7]=1[O:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([N:15]([CH3:17])[CH3:16])[CH:10]=1.C(=O)([O-])[O-].[K+].[K+].CN(C)[C:33]1C=C(O)C=C[CH:38]=1>CN(C=O)C>[F:1][C:2]1[CH:3]=[C:4](/[CH:19]=[C:20](\[CH3:24])/[C:21]([O:23][CH2:33][CH3:38])=[O:22])[CH:5]=[C:6]([F:18])[C:7]=1[O:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([N:15]([CH3:16])[CH3:17])[CH:10]=1

Participants

5

Reactant 3

HCID 74213-(Dimethylamino)phenolHCID 11430Potassium CarbonateHCID 67586931HCID 67586931, compound

Product 1

HCID 67568574HCID 67568574, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

E-3-[3,5-Difluoro-4-(3-dimethylaminophenoxy)phenyl]-2-methyl-propenoic acid guanidide hydrochloride ##STR15## 10 a) The ester from 8 a, 3 eq. of potassium carbonate and 1.1 eq. of 3-dimethylaminophenol were stirred in DMF at 150° C. for 5 hours. After working up and purification, ethyl E-3-[3,5-difluoro-4-(3-dimethylaminophenoxy)phenyl]-2-methyl-propenoate was isolated.

Workup

  1. custompurification

Sources & evidence

ORD record
ord-3537327bb628406280c0f8d83cd313a8
Source dataset
uspto-grants-1999_03
Patent number
US05883133

Reaction notes

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