3-(Dimethylamino)phenol → HCID 67587604, compound

HRID 1418601Notes

Reaction equation

HRID 1418601 reaction equation
F[C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[C:4]([F:9])[C:3]=1/[CH:10]=[C:11](\[CH3:17])/[C:12]([O:14]CC)=[O:13].C(=O)([O-])[O-].[K+].[K+].[CH3:24][N:25]([CH3:33])[C:26]1[CH:27]=[C:28]([OH:32])[CH:29]=[CH:30][CH:31]=1>CN(C=O)C>[F:9][C:4]1[CH:5]=[C:6]([F:8])[CH:7]=[C:2]([O:32][C:28]2[CH:29]=[CH:30][CH:31]=[C:26]([N:25]([CH3:33])[CH3:24])[CH:27]=2)[C:3]=1/[CH:10]=[C:11](\[CH3:17])/[C:12]([OH:14])=[O:13]

Participants

5

Reactant 3

HCID 74213-(Dimethylamino)phenolHCID 11430Potassium CarbonateHCID 67568187HCID 67568187, compound

Product 1

HCID 67587604HCID 67587604, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

11 b/12 b) The ester from 11 a/12 ma, 3 eq. of potassium carbonate and 1.1 eq. of 3-dimethylaminophenol were stirred in DMF at 150° C. for 3 hours. An isomer mixture of the ethyl esters of E-3-[2,6-difluoro-4-(3-dimethylaminophenoxy)]-2-methyl-propenoic acid and E-3-[2,4-difluoro-6-(3-dimethylaminophenoxy)-phenyl]-2-methyl-propenoic acid was isolated.

Sources & evidence

ORD record
ord-7c3f6a4988cc47ff9775e91164541a0a
Source dataset
uspto-grants-1999_03
Patent number
US05883133

Reaction notes

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