Hydrochloric Acid → HCID 86753979, compound

HRID 1419098Notes

Reaction equation

HRID 1419098 reaction equation
[OH:1][C:2]1[C:27]([CH3:28])=[C:26]([CH3:29])[C:5]2[N:6]([CH3:25])[C:7]([CH2:9][O:10][C:11]3[CH:24]=[CH:23][C:14]([CH2:15][CH:16]4[S:20][C:19](=[O:21])[NH:18][C:17]4=[O:22])=[CH:13][CH:12]=3)=[N:8][C:4]=2[C:3]=1[CH3:30].[ClH:31]>C(OCC)(=O)C>[ClH:31].[OH:1][C:2]1[C:27]([CH3:28])=[C:26]([CH3:29])[C:5]2[N:6]([CH3:25])[C:7]([CH2:9][O:10][C:11]3[CH:24]=[CH:23][C:14]([CH2:15][CH:16]4[S:20][C:19](=[O:21])[NH:18][C:17]4=[O:22])=[CH:13][CH:12]=3)=[N:8][C:4]=2[C:3]=1[CH3:30]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 9867103HCID 9867103, compound

Product 1

HCID 86753979HCID 86753979, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A suspension of 0.12 g of 5-[4-(5-hydroxy-1,4,6,7-tetramethylbenzimidazol-2-ylmethoxy)benzyl]thiazolidine-2,4-dione (prepared as described in Example 3) in 3 ml of a 4N solution of hydrogen chloride in ethyl acetate was stirred for 3 hours at room temperature, after which it was allowed to stand overnight. Insoluble substances were collected by filtration and washed with tetrahydrofuran, with ethyl acetate and with diethyl ether, in that order, to give 0.11 g of the title compound, melting at 228°-231° C.

Workup

  1. waitto stand overnight
  2. filtrationInsoluble substances were collected by filtration
  3. washwashed with tetrahydrofuran, with ethyl acetate and with diethyl ether, in that order

Sources & evidence

ORD record
ord-d5ba8dd676df4abbb885281478f160f1
Source dataset
uspto-grants-1999_03
Patent number
US05886014

Reaction notes

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