4-Phenylpyridine → HCID 67560974, compound

HRID 1419673Notes

Reaction equation

HRID 1419673 reaction equation
Cl.[Cl:2][CH2:3][CH2:4][CH2:5][NH2:6].[C:7]1([C:13]2[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=2)[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>C(OCC)(=O)C>[ClH:2].[C:7]1([C:13]2[CH:14]=[CH:15][N:16]=[C:17]([CH2:3][CH2:4][CH2:5][NH2:6])[CH:18]=2)[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1

Participants

4

Reactant 2

HCID 136514-PhenylpyridineHCID 114690951-Propanamine, 3-chloro-, hydrochloride

Product 1

HCID 67560974HCID 67560974, compoundYield 70.4%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Conditions

Temperature
70 °C

Procedure

3-Chloropropylamine hydrochloride (13.0 g) and 15.5 g of 4-phenylpyridine were dissolved in dimethylacetamido and heated at 70° C. for 5 hours. Ethyl acetate was added thereto and the precipitated crystals were collected by filtration to obtain 17.5 g of 3-(4-phenylpyridyl)propylamine hydrochloride.

Workup

  1. filtrationthe precipitated crystals were collected by filtration

Sources & evidence

ORD record
ord-9654b29182c94a17a68863ef59db35a0
Source dataset
uspto-grants-1999_03
Patent number
US05888694

Reaction notes

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