Methanol → HCID 10562328, compound

HRID 1420295Notes

Reaction equation

CO.[CH2:3]([NH2:6])[CH2:4][CH3:5].C[Si](C)(C)[C:9]#[C:10][C:11]1[C:17]([Si](C)(C)C)=[C:16]([OH:22])[C:15]([CH3:23])=[C:14]([CH3:24])[C:12]=1[OH:13].[C:27](OCC)(=O)[CH3:28]>>[CH2:3]([N:6]1[C:10]([CH3:9])=[C:11]2[C:17]([C:16](=[O:22])[C:15]([CH3:23])=[C:14]([CH3:24])[C:12]2=[O:13])=[C:27]1[CH3:28])[CH2:4][CH3:5]

Participants

Reactant 4

HCID 887Methanol

HCID 7852Propylamine

HCID 8857Ethyl Acetate

HCID 86754018HCID 86754018, compound

Product 1

HCID 10562328HCID 10562328, compoundYield 97%

Procedure

Following procedure A MeOH (0.8 mL) and propylamine (0.02 mL) were added to 2 (46.2 mg, 0.14 mmol) and stirred at room temperature for 2 days. Column chromatography with 3% ethyl acetate in petroleum ether gave pure yellow product in 97% yield (33.3 mg). Melting point 165°-167° C.

Sources & evidence

ORD record: ord-9a92e6eb7ca444ddb9e4e34a14f673ec
Source dataset: uspto-grants-1999_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05889185

Reaction notes

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