Water → HCID 11311579, compound

HRID 1420768Notes

Reaction equation

HRID 1420768 reaction equation
[Na].[C:2]([O:6][CH3:7])(=[O:5])[CH2:3][SH:4].C1(S(O[CH:18]=[C:19]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=2[O:28][CH3:29])[C:20]#[N:21])(=O)=O)C=CC=CC=1.O>CO>[NH2:21][C:20]1[C:19]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=2[O:28][CH3:29])=[CH:18][S:4][C:3]=1[C:2]([O:6][CH3:7])=[O:5]

Participants

6

Reactant 4

HCID 962WaterHCID 16907Methyl ThioglycolateHCID 5360545SodiumHCID 57066737alpha-(Phenylsulphonyloxymethylidene)-2-methoxyphenylacetonitrile

Product 1

HCID 11311579HCID 11311579, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

11 mmol of sodium are dissolved in 100 ml of methanol. After cooling the reaction mixture using an ice bath, 4.5 mmol of methyl thioglycolate and then 3.7 mmol of the compound obtained in Step B are added. After 2 hours' reaction, 100 ml of water are added, bringing about the formation of a precipitate, which is filtered off and then dried, allowing the to expected product to be isolated.

Workup

  1. temperatureAfter cooling the reaction mixture
  2. additionare added
  3. filtrationis filtered off
  4. customdried
  5. customto be isolated

Sources & evidence

ORD record
ord-6bb6e1869add43ff9cb4880ebd322549
Source dataset
uspto-grants-2000_06
Patent number
US06071945

Reaction notes

Loading…