反应详情

To a stirred solution of 5-chloro-5'-(1-triphenylmethyl-1H-imidazol-4-ylmethyl)-[1,2']bipyridinyl-2-one from Example 23 step 5 (1.00 g, 1.89 mmol) in CH2Cl2 (15 mL) was added trifluoroacetic acid (0.86 g, 7.6 mmol) and the dark yellow solution was stirred for 5 min at ambient temperature. Triethylsilane was added dropwise until the yellow color was dissipated and the solution was concentrated in vacuo. The residue was purified by flash column chromatography, eluting with CH2Cl2 ; 1% MeOH; 0.1% NH4OH, to give the title compound:

1. concentrationthe solution was concentrated in vacuo
2. customThe residue was purified by flash column chromatography
3. washeluting with CH2Cl2