Hydrochloric Acid → N-(7-Bromo-2,3-dimethoxyquinoxalin-5-ylmethyl)-oxalamic acid

HRID 1422228Notes

Reaction equation

HRID 1422228 reaction equation
C([O:3][C:4](=[O:24])[C:5]([NH:7][CH2:8][C:9]1[CH:18]=[C:17]([Br:19])[CH:16]=[C:15]2[C:10]=1[N:11]=[C:12]([O:22][CH3:23])[C:13]([O:20][CH3:21])=[N:14]2)=[O:6])C.C(=O)([O-])[O-].[K+].[K+].Cl>O.CO>[Br:19][C:17]1[CH:16]=[C:15]2[C:10]([N:11]=[C:12]([O:22][CH3:23])[C:13]([O:20][CH3:21])=[N:14]2)=[C:9]([CH2:8][NH:7][C:5](=[O:6])[C:4]([OH:24])=[O:3])[CH:18]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 11430Potassium CarbonateHCID 54297612N-(7-bromo-2,3-dimethoxy-quinoxalin-5-ylmethyl)-oxalamic acid ethyl ester

Product 1

HCID 18706444N-(7-Bromo-2,3-dimethoxyquinoxalin-5-ylmethyl)-oxalamic acid

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

276 mg of N-(7-bromo-2,3-dimethoxy-quinoxalin-5-ylmethyl)-oxalamic acid ethyl ester and 150 mg of potassium carbonate are suspended in 2 ml of water and 5 ml of methanol. The mixture is stirred for 20 hours and acidified with 1 N HCl, and the solid is filtered off and washed with methanol and diethyl ether. M.p.>300° C.

Workup

  1. filtrationthe solid is filtered off
  2. washwashed with methanol and diethyl ether

Sources & evidence

ORD record
ord-34cd457fe3404f18af1c006d095a5696
Source dataset
uspto-grants-2000_06
Patent number
US06080743

Reaction notes

Loading…