Trityl chloride → HCID 18779112, compound

HRID 1422342Notes

Reaction equation

HRID 1422342 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([O:9][C:10]2[N:11]=[CH:12][NH:13][CH:14]=2)=[CH:5][CH:4]=1)#[N:2].[C:15](Cl)([C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>CN(C=O)C>[C:1]([C:3]1[CH:8]=[CH:7][C:6]([O:9][C:10]2[N:11]=[CH:12][N:13]([C:15]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)([C:28]3[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=3)[C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=3)[CH:14]=2)=[CH:5][CH:4]=1)#[N:2]

Participants

4

Reactant 2

HCID 6456Trityl chlorideHCID 178510085HCID 178510085, compound

Product 1

HCID 18779112HCID 18779112, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a cold (0° C.) solution of 4-(4-cyanophenyloxy)-imidazole (155 mg, 0.84 mmol) and triethylanine (0.129 mL, 0.92 mmol) in DMF (1 mL) was added trityl chloride (245 mg, 0.88 mmol). The resultant mixture was stirred at ambient temperature for 5 days. The product mixture was concentrated onto silica gel, chromatographed (Silica gel, 1:9 acetone in CHCl3) to afford the title compound as a white powder.

Workup

  1. concentrationThe product mixture was concentrated onto silica gel
  2. customchromatographed (Silica gel, 1:9 acetone in CHCl3)

Sources & evidence

ORD record
ord-6bd7f7ebc0ba44e1a7f6536b1ce904d6
Source dataset
uspto-grants-2000_06
Patent number
US06080870

Reaction notes

Loading…