Hydrochloric Acid → (6-Chloro-2-methylpyridin-3-YL)methanamine

HRID 1422405Notes

Reaction equation

HRID 1422405 reaction equation
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([CH3:10])[N:3]=1.[BH4-].[Na+].B(F)(F)F.Cl>C1COCC1.CO>[Cl:1][C:2]1[N:3]=[C:4]([CH3:10])[C:5]([CH2:6][NH2:7])=[CH:8][CH:9]=1

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 6356Boron trifluorideHCID 4311764Sodium borohydrideHCID 123877376-Chloro-2-methylnicotinonitrile

Product 1

HCID 59534442(6-Chloro-2-methylpyridin-3-YL)methanamine

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 6-Chloro-2-methyl-nicotinonitrile (6 g) in THF (120 ml) at 25° C. was added NaBH4 (3 g) followed by the dropwise addition of BF3 etherate (6 ml). The reaction mixture was stirred for 3 h. MeOH (100 ml) and 2N HCl (100 ml) was added and refluxed for 1 h. The organic solvent was removed in vacuum and conc. NaOH (40 ml) was added followed by extraction with diethyl ether. The organic layer was separated, dried and concentrated in vacuum followed by filtration over silica gel (EtOAc/MeOH 80:20). The title compound was crystallized from MeOH/HCl (5.5 g)

Workup

  1. temperaturerefluxed for 1 h
  2. customThe organic solvent was removed in vacuum and conc. NaOH (40 ml)
  3. additionwas added
  4. extractionfollowed by extraction with diethyl ether
  5. customThe organic layer was separated
  6. customdried
  7. concentrationconcentrated in vacuum
  8. filtrationfollowed by filtration over silica gel (EtOAc/MeOH 80:20)
  9. customThe title compound was crystallized from MeOH/HCl (5.5 g)

Sources & evidence

ORD record
ord-f8fd971dead7488bb82dad890aff32aa
Source dataset
uspto-grants-2015_01
Patent number
USRE045323E1

Reaction notes

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