Ammonium Hydroxide → HCID 86699115, compound

HRID 1424202Notes

Reaction equation

HRID 1424202 reaction equation
[C:1]([C:5]1[CH:6]=[CH:7][C:8]2[N:9]([CH:11]=[C:12]([C@@H:14]3[C@@H:17]([CH3:18])[C:16](=[O:19])[N:15]3[C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[N:13]=2)[CH:10]=1)([CH3:4])([CH3:3])[CH3:2].[OH-].[NH4+:28]>C1COCC1>[NH2:28][C:16](=[O:19])[C@H:17]([CH3:18])[C@H:14]([NH:15][C:20](=[O:21])[O:22][C:23]([CH3:24])([CH3:26])[CH3:25])[C:12]1[N:13]=[C:8]2[CH:7]=[CH:6][C:5]([C:1]([CH3:2])([CH3:4])[CH3:3])=[CH:10][N:9]2[CH:11]=1

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 86699116HCID 86699116, compound

Product 1

HCID 86699115HCID 86699115, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
50 °C

Procedure

(2S,3R)-tert-butyl 2-(6-(tert-butyl)imidazo[1,2-a]pyridin-2-yl)-3-methyl-4-oxoazetidine-1-carboxylate (Preparation 38) was dissolved in THF (10 mL) and excess 28% aqueous ammonium hydroxide solution (ca 3 mL) added. The reaction was stirred in a sealed vial at 50° C. for 18 hours. The solvent was removed in vacuo to afford 311 mg of the title compound.

Workup

  1. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-d32c11a9c345437b8ba49c6fe01ea5d6
Source dataset
uspto-grants-2015_01
Patent number
US08927587B2

Reaction notes

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