反应详情

45 mg (0.074 mmol) of (8), 50 mg (0.123 mmol) of (7), 48 mg (0.148 mmol) of Cs2CO3, 16 mg (0.024 mmol) of Pd(dba)2-CHCl3 and 43 mg (0.074 mmol) of Xantphos were heated under argon for 3 hours. After diluting with 50 ml ethyl acetate and washing two times with saturated aqueous NaHCO3 and one time with brine the solution was dried over Na2SO4 and concentrated in vacuo. 70 mg of crude (15) were obtained as yellow foam.

1. washwashing two times with saturated aqueous NaHCO3 and one time with brine the solution
2. dry with materialwas dried over Na2SO4
3. concentrationconcentrated in vacuo