4-Bromobiphenyl → 4-Hydroxybiphenyl

HRID 1424759Notes

Reaction equation

HRID 1424759 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[OH-:14].[Cs+]>C(OCC)(=O)C.CCCCCCC>[C:5]1([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:6]=[CH:7][C:2]([OH:14])=[CH:3][CH:4]=1

Participants

4

Reactant 2

HCID 71014-BromobiphenylHCID 62750Cesium hydroxide

Product 1

HCID 71034-HydroxybiphenylYield 90%

Reagents, catalysts & solvents 1

HCID 21899848Ethylacetate heptaneSolvent

Procedure

Following general operating mode B, 4-bromobiphenyl (232 mg, 1.0 mmol) was reacted with cesium hydroxide to give the expected product in the form of a brown solid with a yield of 90% (eluent: ethyl acetate/heptane 20:80).

Sources & evidence

ORD record
ord-5f608057189d404caba85d86233e4dfe
Source dataset
uspto-grants-2015_01
Patent number
US08927779B2

Reaction notes

Loading…