Sodium ion → 5-(2,4-dichlorophenyl)-N-(4-ethoxypyrrolidin-3-yl)-3,6-diethylpyrazin-2-amine

HRID 142624Notes

Reaction equation

HRID 142624 reaction equation
[CH2:38]([SiH:39]([CH2:40][CH3:41])[CH2:42][CH3:43])[CH3:44].[CH2:54]([Cl:55])[Cl:56].[CH3:60][CH2:61][N:62]([CH2:63][CH3:64])[CH2:65][CH3:66].[Cl:1][c:2]1[c:3](-[c:9]2[n:10][c:11]([CH2:36][CH3:37])[c:12]([NH:17][CH:18]3[CH2:19][N:20]([C:26]([O:27][CH2:28][c:29]4[cH:30][cH:31][cH:32][cH:33][cH:34]4)=[O:35])[CH2:21][CH:22]3[O:23][CH2:24][CH3:25])[n:13][c:14]2[CH2:15][CH3:16])[cH:4][cH:5][c:6]([Cl:8])[cH:7]1.[Na+:53].[OH-:52].[OH:45][C:46]([C:47]([F:48])([F:49])[F:50])=[O:51].[Pd:57]([Cl:58])[Cl:59]>>[Cl:1][c:2]1[c:3](-[c:9]2[n:10][c:11]([CH2:36][CH3:37])[c:12]([NH:17][CH:18]3[CH2:19][NH:20][CH2:21][CH:22]3[O:23][CH2:24][CH3:25])[n:13][c:14]2[CH2:15][CH3:16])[cH:4][cH:5][c:6]([Cl:8])[cH:7]1

Participants

9

Reactant 8

HCID 923Sodium ionHCID 961HydroxideHCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 8471TriethylamineHCID 12052TriethylsilaneHCID 24290Palladium ChlorideHCID 22147242HCID 22147242, compound

Product 1

HCID 101944255-(2,4-dichlorophenyl)-N-(4-ethoxypyrrolidin-3-yl)-3,6-diethylpyrazin-2-amine

Sources & evidence

ORD record
ord-f6082d4d0f2b4e11a9d76e43e47faca2
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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