Dimethylformamide → HCID 67396667, compound

HRID 1426747Notes

Reaction equation

HRID 1426747 reaction equation
Br[C:2]1[C:3]([S:7]([N:10]2[C:14]([C:15]3[C:16]([F:21])=[N:17][CH:18]=[CH:19][CH:20]=3)=[C:13]([F:22])[C:12]([CH2:23][N:24]([CH3:32])[C:25](=[O:31])[O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[CH:11]2)(=[O:9])=[O:8])=[CH:4][S:5][CH:6]=1.[CH3:33][N:34](C)C=O>C(OCC)(=O)C.[C-]#N.[Zn+2].[C-]#N.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd]>[C:33]([C:2]1[C:3]([S:7]([N:10]2[C:14]([C:15]3[C:16]([F:21])=[N:17][CH:18]=[CH:19][CH:20]=3)=[C:13]([F:22])[C:12]([CH2:23][N:24]([CH3:32])[C:25](=[O:31])[O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[CH:11]2)(=[O:9])=[O:8])=[CH:4][S:5][CH:6]=1)#[N:34]

Participants

6

Reactant 2

HCID 6228DimethylformamideHCID 67398033HCID 67398033, compound

Product 1

HCID 67396667HCID 67396667, compoundYield 88%

Reagents, catalysts & solvents 3

HCID 11186Zinc cyanide (Zn(CN)2)CatalystHCID 9811564Bis(dibenzylideneacetone)palladiumCatalystHCID 8857Ethyl AcetateSolvent

Conditions

Temperature
120 °C

Procedure

To a solution of tert-butyl {[1-[(4-bromo-3-thienyl)sulfonyl]-4-fluoro-5-(2-fluoropyridin-3-yl)-1H-pyrrol-3-yl]methyl}methylcarbamate (229 mg) in dimethylformamide (3 mL) was added zinc cyanide (74.6 mg) at room temperature, and the mixture was sufficiently deaerated under an argon atmosphere. Tetrakis(triphenylphosphine)palladium (0) (145 mg) was added and the mixture was further deaerated and stirred at 120° C. for 2 hr. The reaction mixture was diluted with ethyl acetate and filtrated. The filtrate was washed with water, and separated aqueous layer was extracted again with ethyl acetate. The combined organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: hexane-ethyl acetate=9:1→3:2) to give the title compound as a pale-yellow oil (yield 181 mg, 88%).

Workup

  1. filtrationfiltrated
  2. washThe filtrate was washed with water
  3. customseparated aqueous layer
  4. extractionwas extracted again with ethyl acetate
  5. washThe combined organic layer was washed with saturated brine
  6. dry with materialdried over anhydrous magnesium sulfate
  7. concentrationconcentrated under reduced pressure
  8. customThe residue was purified by silica gel column chromatography (eluent: hexane-ethyl acetate=9:1→3:2)

Sources & evidence

ORD record
ord-aa4c49c0c0b246ccac6454264b9f55bc
Source dataset
uspto-grants-2015_01
Patent number
US08933105B2

Reaction notes

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