反应详情

HOAt (23 mg), HATU (97 mg), DMAP (10 mg) and DIPEA (50 μl) were added to a solution of 5-(4-fluorophenyl)-1-methyl-4-oxo-1,4-dihydropyridine-3-carboxylic acid (46 mg) in DMF (1 ml) at room temperature. The reaction mixture was stirred at room temperature for three hours. The compound obtained in Step 2 of Example 1 (55 mg) was added to the reaction mixture at room temperature. The reaction mixture was stirred at room temperature overnight. Water was added to the reaction mixture, and the precipitated solid was collected by filtration. The resulting solid was purified by PLC [ethyl acetate:methanol=20:1 (v/v)] to give 19 mg of the title compound as a solid.

1. stirringThe reaction mixture was stirred at room temperature overnight
2. filtrationthe precipitated solid was collected by filtration
3. customThe resulting solid was purified by PLC [ethyl acetate:methanol=20:1 (v/v)]