Hydrochloric Acid → HCID 86700081, compound

HRID 1428136Notes

Reaction equation

HRID 1428136 reaction equation
C(O)CC.[ClH:5].[NH2:6][C:7]1[C:12]([C:13]2[CH:18]=[CH:17][C:16]([NH:19][C:20]([C:22]3[C:27](=[O:28])[C:26]([C:29]4[CH:34]=[CH:33][C:32]([F:35])=[CH:31][CH:30]=4)=[CH:25][N:24]([CH2:36][C:37]([F:40])([F:39])[F:38])[CH:23]=3)=[O:21])=[CH:15][CH:14]=2)=[CH:11][C:10]([C:41]2[CH:46]=[CH:45][C:44]([O:47][CH3:48])=[C:43]([O:49][CH3:50])[CH:42]=2)=[CH:9][N:8]=1>O>[ClH:5].[NH2:6][C:7]1[C:12]([C:13]2[CH:14]=[CH:15][C:16]([NH:19][C:20]([C:22]3[C:27](=[O:28])[C:26]([C:29]4[CH:30]=[CH:31][C:32]([F:35])=[CH:33][CH:34]=4)=[CH:25][N:24]([CH2:36][C:37]([F:38])([F:39])[F:40])[CH:23]=3)=[O:21])=[CH:17][CH:18]=2)=[CH:11][C:10]([C:41]2[CH:46]=[CH:45][C:44]([O:47][CH3:48])=[C:43]([O:49][CH3:50])[CH:42]=2)=[CH:9][N:8]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 10311-PropanolHCID 71698834HCID 71698834, compound

Product 1

HCID 86700081HCID 86700081, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
40 °C

Procedure

1-Propanol (401 μl), a 5.877 mmol/L aqueous hydrochloric acid solution (6.22 μl, 1.10 eq.) and water (4.1 μl) were added to N-{4-[2-amino-5-(3,4-dimethoxyphenyl)pyridin-3-yl]phenyl}-5-(4-fluorophenyl)-4-oxo-1-(2,2,2-trifluoroethyl)-1,4-dihydropyridine-3-carboxamide (20.55 mg, 33.22 μmol) at room temperature, and the mixture was stirred at 40° C. for about 24 hours. After leaving to stand at room temperature for about 30 minutes, the precipitated solid was collected by filtration. The solid was then dried at room temperature to give the title compound (19.65 mg). Yield: 90%.

Workup

  1. customAfter leaving
  2. waitto stand at room temperature for about 30 minutes
  3. filtrationthe precipitated solid was collected by filtration
  4. customThe solid was then dried at room temperature

Sources & evidence

ORD record
ord-f735c90d0b434930b8a2cf800c1bd0df
Source dataset
uspto-grants-2015_01
Patent number
US08933103B2

Reaction notes

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