Hydrochloric Acid → HCID 117652382, compound

HRID 1428388Notes

Reaction equation

HRID 1428388 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([N:6]=[CH:7][C:8](=[O:18])[N:9]2[CH2:12][C:13]([O:15]CC)=[O:14])=[CH:4][CH:3]=1.[OH-].[Na+].Cl>C1COCC1>[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([N:6]=[CH:7][C:8](=[O:18])[N:9]2[CH2:12][C:13]([OH:15])=[O:14])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 117660479HCID 117660479, compound

Product 1

HCID 117652382HCID 117652382, compoundYield 92.5%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a mixture of ethyl (7-chloro-2-oxoquinoxalin-1(2H)-yl)acetate (2.21 g) and THF (25 mL) was added a 1 M aqueous NaOH solution (9.0 mL) at room temperature, followed by stirring at the same temperature for 4 hours. The reaction mixture was acidified by the addition of 1 M hydrochloric acid solution and then concentrated under reduced pressure. To the residue was added water, followed by stirring and collecting by filtration. The obtained solid was washed with water to obtain (7-chloro-2-oxoquinoxalin-1(2H)-yl)acetic acid (1.83 g).

Workup

  1. concentrationconcentrated under reduced pressure
  2. additionTo the residue was added water
  3. stirringby stirring
  4. filtrationcollecting by filtration
  5. washThe obtained solid was washed with water

Sources & evidence

ORD record
ord-16e183b806f14e3c87ac56ac0f1e9a83
Source dataset
uspto-grants-2015_01
Patent number
US08937087B2

Reaction notes

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