Hydrochloric Acid → 3-Chloro-1-(naphthalen-2-yl)propan-1-one

HRID 1428430Notes

Reaction equation

HRID 1428430 reaction equation
ClCC[CH2:4][CH2:5][C:6](Cl)=[O:7].[CH:9]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:12]=[CH:11][CH:10]=1.[Cl-:19].[Al+3].[Cl-].[Cl-].Cl>[N+](C1C=CC=CC=1)([O-])=O>[Cl:19][CH2:4][CH2:5][C:6]([C:15]1[CH:16]=[CH:17][C:18]2[C:13](=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:14]=1)=[O:7]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 931NaphthaleneHCID 740895-Chlorovaleryl chlorideHCID 6451240Aluminum(III) Chloride

Product 1

HCID 126989383-Chloro-1-(naphthalen-2-yl)propan-1-oneYield 38.3%

Reagents, catalysts & solvents 1

HCID 7416NitrobenzeneSolvent

Procedure

2-chloroethylpropionyl chloride (2.78 g), naphthalene (2.56 g), and aluminium chloride (3.2 g) were reacted in nitrobenzene (9 mL) at 0° C., followed by treatment with hydrochloric acid to obtain the title compound (1.5 g).

Sources & evidence

ORD record
ord-6f584296aa404fb38203d9e4b19fff00
Source dataset
uspto-grants-2015_01
Patent number
US08937091B2

Reaction notes

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