Hydrochloric Acid → 3-Chloro-1-(4-methylphenyl)propan-1-one

HRID 1428432Notes

Reaction equation

HRID 1428432 reaction equation
ClCC[CH2:4][CH2:5][C:6](Cl)=[O:7].[C:9]1(C)C=CC=CC=1.[Cl-:16].[Al+3].[Cl-].[Cl-].Cl.[N+]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)([O-])=O>>[Cl:16][CH2:4][CH2:5][C:6]([C:24]1[CH:29]=[CH:28][C:27]([CH3:9])=[CH:26][CH:25]=1)=[O:7]

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 1140TolueneHCID 7416NitrobenzeneHCID 740895-Chlorovaleryl chlorideHCID 6451240Aluminum(III) Chloride

Product 1

HCID 2350843-Chloro-1-(4-methylphenyl)propan-1-one

Procedure

2-chloroethylpropionyl chloride (0.63 g), toluene (0.885 g), and aluminium chloride (0.8 g) were reacted in nitrobenzene (1 mL) at 0° C., followed by treatment with hydrochloric acid to obtain the title compound (0.25 g).

Sources & evidence

ORD record
ord-4e77235c4727400e95c922968ed11538
Source dataset
uspto-grants-2015_01
Patent number
US08937091B2

Reaction notes

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