反应详情

温度

120 °C

To a stirred solution of ethyl 2-(4-iodo-3-methoxyphenyl)propanoate (626 mg, 1.873 mmol) in dimethylformamide were added zinc cyanide (227 mg, 1.929 mmol) and tetrakis(triphenylphosphine) palladium (216 mg, 0.1873 mmol). The reaction mixture was stirred for 36 h at 120° C., then cooled to room temperature, diluted with ethyl acetate. The mixture was filtered using celite pad. The filtrate dissolved in ethyl acetate and extracted with NaHCO3. The organic layer was dried over magnesium sulfate and filtered. The filtrate removed in vacuo. The crude was purified by column chromatography. Ethyl 2-(4-cyano-3-methoxyphenyl)propanoate (222 mg) was obtained as 51% yield.

1. temperaturecooled to room temperature
2. filtrationThe mixture was filtered
3. dissolutionThe filtrate dissolved in ethyl acetate
4. extractionextracted with NaHCO3
5. dry with materialThe organic layer was dried over magnesium sulfate
6. filtrationfiltered
7. customThe filtrate removed in vacuo
8. customThe crude was purified by column chromatography