Trifluoroacetic acid → HCID 68592566, compound

HRID 1429146Notes

Reaction equation

HRID 1429146 reaction equation
C([O:5][C:6]([CH:8]1[CH2:12][CH:11]([O:13][C:14]2[CH:19]=[C:18]([O:20][CH3:21])[N:17]=[C:16]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[N:15]=2)[CH2:10][CH:9]1[C:28](=[O:40])[NH:29][C:30]1([C:35]([O:37][CH2:38][CH3:39])=[O:36])[CH2:32][CH:31]1[CH:33]=[CH2:34])=[O:7])(C)(C)C.C([SiH](CC)CC)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH2:38]([O:37][C:35]([C:30]1([NH:29][C:28]([CH:9]2[CH2:10][CH:11]([O:13][C:14]3[CH:19]=[C:18]([O:20][CH3:21])[N:17]=[C:16]([C:22]4[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=4)[N:15]=3)[CH2:12][CH:8]2[C:6]([OH:7])=[O:5])=[O:40])[CH2:32][CH:31]1[CH:33]=[CH2:34])=[O:36])[CH3:39]

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 12052TriethylsilaneHCID 68592472HCID 68592472, compound

Product 1

HCID 68592566HCID 68592566, compoundYield 99.4%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Compound 7a (1.48 g, 2.68 mmol) was dissolved in 35 ml DCM. Triethylsilane (1.07 ml, 6.7 mmol) and 35 ml TFA were added and the mixture was stirred at RT for 45 minutes. The solvent was evaporated and co evaporated with toluene which gave the title product (1.32 g, 99%), MS (M+H)+496.

Workup

  1. customThe solvent was evaporated
  2. customco evaporated with toluene which

Sources & evidence

ORD record
ord-d9200c526a2f4821a33935f4f2627ddd
Source dataset
uspto-grants-2015_01
Patent number
US08937080B2

Reaction notes

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