Triethylsilane → HCID 68590308, compound

HRID 1429166Notes

Reaction equation

HRID 1429166 reaction equation
C([O:5][C:6]([CH:8]1[CH2:12][CH:11]([O:13][C:14]2[CH:19]=[C:18]([C:20]3[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][CH:21]=3)[N:17]=[C:16]([O:28][CH3:29])[N:15]=2)[CH2:10][CH:9]1[C:30](=[O:42])[NH:31][C:32]1([C:37]([O:39][CH2:40][CH3:41])=[O:38])[CH2:34][CH:33]1[CH:35]=[CH2:36])=[O:7])(C)(C)C.C([SiH](CC)CC)C>C(O)(C(F)(F)F)=O>[CH2:40]([O:39][C:37]([C:32]1([NH:31][C:30]([CH:9]2[CH2:10][CH:11]([O:13][C:14]3[CH:19]=[C:18]([C:20]4[CH:21]=[CH:22][C:23]([O:26][CH3:27])=[CH:24][CH:25]=4)[N:17]=[C:16]([O:28][CH3:29])[N:15]=3)[CH2:12][CH:8]2[C:6]([OH:7])=[O:5])=[O:42])[CH2:34][CH:33]1[CH:35]=[CH2:36])=[O:38])[CH3:41]

Participants

4

Reactant 2

HCID 12052TriethylsilaneHCID 68591327HCID 68591327, compound

Product 1

HCID 68590308HCID 68590308, compoundYield 130.2%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

Compound 16b (1.11 g, 1.9 mmol) was treated with triethylsilane (0.55 g, 4.75 mmol) and TFA (30 ml) according to the procedure described in Example 13 step b which gave the crude title compound, (1.3 g), (M+H)+526.

Sources & evidence

ORD record
ord-b79ff7b0ab444534adae7db7c196cf24
Source dataset
uspto-grants-2015_01
Patent number
US08937080B2

Reaction notes

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