Trifluoroacetic acid → HCID 68592521, compound

HRID 1429172Notes

Reaction equation

HRID 1429172 reaction equation
C([O:5][C:6]([CH:8]1[CH2:12][CH:11]([O:13][C:14]2[CH:19]=[C:18]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[N:17]=[C:16]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[N:15]=2)[CH2:10][CH:9]1[C:32](=[O:44])[NH:33][C:34]1([C:39]([O:41][CH2:42][CH3:43])=[O:40])[CH2:36][CH:35]1[CH:37]=[CH2:38])=[O:7])(C)(C)C.C([SiH](CC)CC)C.C(O)(C(F)(F)F)=O>>[C:26]1([C:16]2[N:15]=[C:14]([O:13][CH:11]3[CH2:12][CH:8]([C:6]([OH:7])=[O:5])[CH:9]([C:32](=[O:44])[NH:33][C:34]4([C:39]([O:41][CH2:42][CH3:43])=[O:40])[CH2:36][CH:35]4[CH:37]=[CH2:38])[CH2:10]3)[CH:19]=[C:18]([C:20]3[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=3)[N:17]=2)[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 12052TriethylsilaneHCID 68588666HCID 68588666, compound

Product 1

HCID 68592521HCID 68592521, compoundYield 110.8%

Procedure

Compound 17b (1.2 g, 2 mmol) was treated with triethylsilane (0.58 g, 5.0 mmol) and TFA (25 ml) according to the procedure described in Example 13 step b, which gave the crude title compound, (1.2 g), (M+H)+542.

Sources & evidence

ORD record
ord-759135089656412b9a849d615d42b322
Source dataset
uspto-grants-2015_01
Patent number
US08937080B2

Reaction notes

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