Potassium Carbonate → HCID 71269598, compound

HRID 1429403Notes

Reaction equation

HRID 1429403 reaction equation
Br[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][CH2:10][CH2:11][CH:12]([NH2:20])[CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.C([O-])([O-])=O.[K+].[K+]>C1COCC1>[CH2:13]([CH:12]1[NH:20][CH2:2][C:3]2[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=2[CH2:9][CH2:10][CH2:11]1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 67382426HCID 67382426, compound

Product 1

HCID 71269598HCID 71269598, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 30k (crude 1.58 mmol) in THF (10 mL) was added K2CO3 (436 mg, 3.16 mmol). The mixture was left to stir at rt until LC-MS analysis indicated the total consumption of the SM. Then the solid was removed by filtration and the solution was concentrated under reduced pressure to obtain the crude desired product. It was used without further purification in the next step.

Workup

  1. waitThe mixture was left
  2. customthe total consumption of the SM
  3. customThen the solid was removed by filtration
  4. concentrationthe solution was concentrated under reduced pressure

Sources & evidence

ORD record
ord-639ff69a1630434ea00a48216a3e7748
Source dataset
uspto-grants-2015_01
Patent number
US08940722B2

Reaction notes

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