反应详情

温度

80 °C

To a degassed solution of 6-bromo-2-(1-(5-propylpyrimidin-2-yl)piperidin-4-yloxy)benzo[d]thiazole (35 mg, 0.081 mmol), piperidin-4-yl(pyrrolidin-1-yl)methanone nitrate salt (39.5 mg, 0.162 mmol), sodium tert-butoxide (31.0 mg, 0.323 mmol), and BINAP (1.0 mg, 1.61 mmol) in toluene (1 mL) was added Pd2(dba)3 (4.5 mg, 5 mmol). The reaction mixture was stirred at 80° C. overnight. The reaction mixture was cooled to rt, diluted with water (3 mL), and extracted with EtOAc (3×4 mL). The combined organic layers were dried (Na2SO4), filtered, and concentrated. The crude product was purified by column chromatography (silica gel, CH2Cl2-EtOAc gradient 0 to 100% EtOAc) to afford (1-(2-(1-(5-propylpyrimidin-2-yl)piperidin-4-yloxy)benzo[d]thiazol-6-yl)piperidin-4-yl)(pyrrolidin-1-yl)methanone (6 mg, 10.66 μmol, 13% yield) as a white solid. 1H NMR (500 MHz, CDCl3) δ 8.19 (d, J=2.2 Hz, 2H), 7.57 (dd, J=8.9, 2.3 Hz, 1H), 7.23-7.18 (m, 1H), 7.09-7.03 (m, 1H), 5.47-5.37 (m, 1H), 4.28-4.18 (m, 2H), 3.78-3.62 (m, 4H), 3.58-3.48 (m, 4H), 2.77 (t, J=12.1 Hz, 2H), 2.55-2.46 (m, 1H), 2.45-2.40 (m, 2H), 2.24-2.14 (m, 2H), 2.12-1.82 (m, 10H), 1.64-1.58 (m, 2H), 0.97 (td, J=7.3, 2.5 Hz, 3H). LCMS (m/z)=535 (M+H)+.

1. temperatureThe reaction mixture was cooled to rt
2. extractionextracted with EtOAc (3×4 mL)
3. dry with materialThe combined organic layers were dried (Na2SO4)
4. filtrationfiltered
5. concentrationconcentrated
6. customThe crude product was purified by column chromatography (silica gel, CH2Cl2-EtOAc gradient 0 to 100% EtOAc)