2-Bromo-5-methylpyrazine → tert-Butyl 4-(2-(1-(5-methylpyrazin-2-yl)piperidin-4-yloxy)benzo[d]thiazol-6-yl)-5,6-dihydropyridine-1 (2H)-carboxylate

HRID 1429587Notes

Reaction equation

HRID 1429587 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([O:7][C:8]2[S:9][C:10]3[CH:16]=[C:15]([C:17]4[CH2:22][CH2:21][N:20]([C:23]([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24])[CH2:19][CH:18]=4)[CH:14]=[CH:13][C:11]=3[N:12]=2)[CH2:3][CH2:2]1.Br[C:31]1[CH:36]=[N:35][C:34]([CH3:37])=[CH:33][N:32]=1.C(O[Na])(C)(C)C>C1(C)C=CC=CC=1.O.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd].C1C=CC(P(C2C(C3C(P(C4C=CC=CC=4)C4C=CC=CC=4)=CC=C4C=3C=CC=C4)=C3C(C=CC=C3)=CC=2)C2C=CC=CC=2)=CC=1>[CH3:37][C:34]1[N:35]=[CH:36][C:31]([N:1]2[CH2:6][CH2:5][CH:4]([O:7][C:8]3[S:9][C:10]4[CH:16]=[C:15]([C:17]5[CH2:22][CH2:21][N:20]([C:23]([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24])[CH2:19][CH:18]=5)[CH:14]=[CH:13][C:11]=4[N:12]=3)[CH2:3][CH2:2]2)=[N:32][CH:33]=1

Participants

8

Reactant 3

HCID 224193462-Bromo-5-methylpyrazineHCID 67468425tert-butyl 4-(2-(piperidin-4-yloxy)benzo[d]thiazol-6-yl)-5,6-dihydropyridine-1(2H)-carboxylateHCID 178418730sodium 2-methylpropan-2-olate

Product 1

HCID 68208488tert-Butyl 4-(2-(1-(5-methylpyrazin-2-yl)piperidin-4-yloxy)benzo[d]thiazol-6-yl)-5,6-dihydropyridine-1 (2H)-carboxylateYield 59.6%

Reagents, catalysts & solvents 4

HCID 634876Binap, (A+-)-CatalystHCID 9811564Bis(dibenzylideneacetone)palladiumCatalystHCID 962WaterSolventHCID 1140TolueneSolvent

Conditions

Temperature
80 °C

Procedure

To a degassed solution of tert-butyl 4-(2-(piperidin-4-yloxy)benzo[d]thiazol-6-yl)-5,6-dihydropyridine-1(2H)-carboxylate (119.4 mg, 0.287 mmol), 2-bromo-5-methylpyrazine (99 mg, 0.575 mmol), t-BuONa (83 mg, 0.862 mmol), and BINAP (3.58 mg, 5.75 μmol) in toluene (2.5 mL) was added Pd2(dba)3 (15.79 mg, 0.017 mmol). The reaction mixture was stirred in a seal vial at 80° C. overnight, then at 90° C. for additional 2.5 h. The mixture was cooled to rt, diluted with water (10 mL), and extracted with EtOAc (3×5 mL). The combined organic layers were washed with brine (8 mL), dried (Na2SO4), and concentrated. The residue was purified by column chromatography (silica gel, hexanes-EtOAc gradient 0 to 70% EtOAc) to afford Compound 50B (86.6 mg, 0.171 mmol, 59% yield) as a light orange solid. 1H NMR (500 MHz, CDCl3) δ 8.11 (s, 1H), 7.97 (s, 1H), 7.62 (dd, J=9.9, 5.0 Hz, 2H), 7.40 (dd, J=8.5, 1.6 Hz, 1H), 6.04 (s, 1H), 5.44 (dt, J=7.6, 3.8 Hz, 1H), 4.09 (s, 2H), 3.97-3.84 (m, 2H), 3.65 (d, J=5.2 Hz, 2H), 3.57-3.43 (m, 2H), 2.55 (s, 2H), 2.41 (s, 3H), 2.28-2.13 (m, 2H), 2.08-1.94 (m, 2H), 1.50 (s, 9H). LCMS (m/z)=508 (M+H)+.

Workup

  1. waitat 90° C. for additional 2.5 h
  2. temperatureThe mixture was cooled to rt
  3. extractionextracted with EtOAc (3×5 mL)
  4. washThe combined organic layers were washed with brine (8 mL)
  5. dry with materialdried (Na2SO4)
  6. concentrationconcentrated
  7. customThe residue was purified by column chromatography (silica gel, hexanes-EtOAc gradient 0 to 70% EtOAc)

Sources & evidence

ORD record
ord-3a4770fe9f40412c8fb0e3eb89313a7b
Source dataset
uspto-grants-2015_01
Patent number
US08940716B2

Reaction notes

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