Hydrochloric Acid → HCID 86726469, compound

HRID 1430077Notes

Reaction equation

HRID 1430077 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C:8]2([F:21])[CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10][CH2:9]2)[CH:3]=1.[ClH:22]>C(OCC)(=O)C>[ClH:1].[ClH:22].[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C:8]2([F:21])[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]2)[CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 71014147HCID 71014147, compound

Product 1

HCID 86726469HCID 86726469, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A solution of tert-butyl 4-(4-chloropyridin-2-yl)-4-fluoropiperidine-1-carboxylate (C4) (0.280 g, 0.890 mmol) in ethyl acetate (10 mL) was saturated with HCl(g). After 1 h, the reaction was concentrated in vacuo to provide 4-chloro-2-(4-fluoropiperidin-4-yl)pyridine dihydrochloride (C5) that gave a mass ion (ES+) of 215.2 for M+H+.

Workup

  1. concentrationthe reaction was concentrated in vacuo

Sources & evidence

ORD record
ord-4428c56b326d4f7098fe5bc2266b56d0
Source dataset
uspto-grants-2015_01
Patent number
US08940765B2

Reaction notes

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