反应详情

A solution of 155 mg (0.7 mmol) 2-but-3-enylamino-6-methoxy-isonicotinic acid (Acid IIIb), 105 mg (0.47 mmol) (R)-3-methyl-1-(4-methyl-5-oxo-tetrahydro-furan-2-yl)hept-6-enyl]-carbamic acid tert-butyl ester and 63 mg (0.42 mmol) HOBt.H2O in 8 ml DMF is cooled to 0°, treated with 107 mg (0.56 mmol) EDC.HCl and stirred at rt for 3 h. The reaction mixture is diluted with EtOAc and washed with 0.5 N aqueous citric acid, 2 M KHCO3 and brine, then dried over Na2SO4, filtered and evaporated. Chromatography on silica gel yields the title product as a colorless oil.

1. washwashed with 0.5 N aqueous citric acid, 2 M KHCO3 and brine
2. dry with materialdried over Na2SO4
3. filtrationfiltered
4. customevaporated