Iodoethane → HCID 68538880, compound

HRID 1432124Notes

Reaction equation

HRID 1432124 reaction equation
[CH3:1][O:2][C:3](=[O:15])[C:4]1[CH:13]=[C:12]([OH:14])[CH:11]=[C:6]([C:7]([O:9][CH3:10])=[O:8])[CH:5]=1.C([O-])([O-])=O.[K+].[K+].[CH2:22](I)[CH3:23]>CN(C=O)C.O>[CH3:10][O:9][C:7](=[O:8])[C:6]1[CH:11]=[C:12]([O:14][CH2:22][CH3:23])[CH:13]=[C:4]([C:3]([O:2][CH3:1])=[O:15])[CH:5]=1

Participants

6

Reactant 3

HCID 6340IodoethaneHCID 11430Potassium CarbonateHCID 830651,3-Benzenedicarboxylic acid, 5-hydroxy-, 1,3-dimethyl ester

Product 1

HCID 68538880HCID 68538880, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

To a suspension of 10 g (47.57 mmol) 5-hydroxy-isophthalic acid dimethyl ester and 9.86 g (71.36 mmol) K2CO3 in 50 ml DMF is added dropwise 7.67 ml (95.1 mmol) ethyl iodide. After the addition the mixture is stirred for 5 h, diluted with water and extracted with TBME. The organic phase is washed with water, dried with sodium sulfate and evaporated to give the title compound.

Workup

  1. additionAfter the addition the mixture
  2. extractionextracted with TBME
  3. washThe organic phase is washed with water
  4. dry with materialdried with sodium sulfate
  5. customevaporated

Sources & evidence

ORD record
ord-b99b72f20004439099dff696073a8997
Source dataset
uspto-grants-2009_11
Patent number
US07612055B2

Reaction notes

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