反应详情

To a solution of 2N-(4-chlorophenylaminocarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (291 mg, 0.880 mmol) and 3-cyanobenzylamine (140 mg, 1.06 mmol) in DMF (7 mL), EDC (254 mg, 1.32 mmol) was added. The mixture was then stirred at room temperature overnight. H2O and EtOAc were added. The organic layer was separated, washed with 1N HCl, dried over Na2SO4, concentrated in vacuo to give a solid. After being trituated with EtOAc/MeOH/CH2Cl2, the white solid was collected, dried on vacuum (148 mg), which was pure enough for the next reaction.

1. customThe organic layer was separated
2. washwashed with 1N HCl
3. dry with materialdried over Na2SO4
4. concentrationconcentrated in vacuo
5. customto give a solid
6. customthe white solid was collected
7. customdried on vacuum (148 mg), which
8. customwas pure enough for the next reaction