反应详情

5-Bromo-2-isobutoxybenzonitrile and triisopropyl borate were dissolved in a mixed solvent of THF and toluene and an n-butyllithium-hexane solution was added dropwise to the solution at a temperature below −60° C. After the temperature was elevated to −20° C., 1 M hydrochloric acid was added and the whole was stirred at room temperature to obtain (3-cyano-4-isobutoxyphenyl)boronic acid. F: 220.

1. additionan n-butyllithium-hexane solution was added dropwise to the solution at a temperature below −60° C
2. customwas elevated to −20° C.