Dimethyl Sulfoxide → HCID 22936580, compound

HRID 1433683Notes

Reaction equation

HRID 1433683 reaction equation
C1([O:7][C:8](=O)[NH:9][C:10]2[CH:15]=[CH:14][C:13]([O:16][C:17]3[C:26]4[C:21](=[CH:22][C:23]([O:30][CH3:31])=[C:24]([C:27](=[O:29])[NH2:28])[CH:25]=4)[N:20]=[CH:19][CH:18]=3)=[CH:12][C:11]=2[CH3:32])C=CC=CC=1.CS(C)=O.[CH3:38][NH2:39].O1CCCC1>C(OCC)(=O)C.O>[C:27]([C:24]1[CH:25]=[C:26]2[C:21](=[CH:22][C:23]=1[O:30][CH3:31])[N:20]=[CH:19][CH:18]=[C:17]2[O:16][C:13]1[CH:14]=[CH:15][C:10]([NH:9][C:8]([NH:39][CH3:38])=[O:7])=[C:11]([CH3:32])[CH:12]=1)(=[O:29])[NH2:28]

Participants

7

Reactant 4

HCID 679Dimethyl SulfoxideHCID 6329MethylamineHCID 8028TetrahydrofuranHCID 58931269HCID 58931269, compound

Product 1

HCID 22936580HCID 22936580, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8857Ethyl AcetateSolvent

Procedure

[4-(6-Carbamoyl-7-methoxy-4-quinolyl)oxy-2-methyl phenyl]carbamic acid phenyl ester (70 mg) was added to dimethylsulfoxide (0.8 ml), and then a methylamine-containing 2N tetrahydrofuran solution (0.4 ml) was added and the mixture was stirred for 5 minutes. Water and ethyl acetate were added to the reaction solution, and the precipitated crystals were filtered out to obtain the title compound (48 mg).

Workup

  1. additionwas added
  2. filtrationthe precipitated crystals were filtered out

Sources & evidence

ORD record
ord-3464af8c524b42df99c50a69a4e76029
Source dataset
uspto-grants-2009_11
Patent number
US07612092B2

Reaction notes

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