Potassium Carbonate → HCID 58930988, compound

HRID 1433694Notes

Reaction equation

HRID 1433694 reaction equation
CC1C=CC(S(O[CH2:12][C@H:13]2[CH2:15][O:14]2)(=O)=O)=CC=1.C(=O)([O-])[O-].[K+].[K+].[Cl:22][C:23]1[CH:24]=[C:25]([CH:41]=[CH:42][C:43]=1[NH:44][C:45]([NH:47][CH:48]1[CH2:50][CH2:49]1)=[O:46])[O:26][C:27]1[C:36]2[C:31](=[CH:32][C:33]([OH:40])=[C:34]([C:37]([NH2:39])=[O:38])[CH:35]=2)[N:30]=[CH:29][CH:28]=1>CN(C)C=O>[Cl:22][C:23]1[CH:24]=[C:25]([CH:41]=[CH:42][C:43]=1[NH:44][C:45]([NH:47][CH:48]1[CH2:50][CH2:49]1)=[O:46])[O:26][C:27]1[C:36]2[C:31](=[CH:32][C:33]([O:40][CH2:15][C@H:13]([OH:14])[CH2:12][N:30]([CH2:31][CH3:32])[CH2:29][CH3:28])=[C:34]([C:37]([NH2:39])=[O:38])[CH:35]=2)[N:30]=[CH:29][CH:28]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 154187Glycidyl tosylate, (R)-HCID 1355660464-[3-Chloro-4-(cyclopropylcarbamamido)phenoxy]-7-hydroxy-6-quinolinecarboxamide

Product 1

HCID 58930988HCID 58930988, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

After adding (2R)oxiran-2-ylmethyl 4-methyl-1-benzenesulfonate (308 mg, 1.35 mmol), potassium carbonate (149 mg, 1.08 mmol) and dimethylformamide (9 ml) to 4-(3-chloro-4-(((cyclopropylamino)carbonyl)amino)phenoxy)-7-hydroxy-6-quinolinecarboxamide (372.0 mg, 0.90 mmol),

Sources & evidence

ORD record
ord-9765dd882fa54b2fb024c34092bffdd3
Source dataset
uspto-grants-2009_11
Patent number
US07612092B2

Reaction notes

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