Diethyl Oxalate → HCID 57435095, compound

HRID 1434764Notes

Reaction equation

HRID 1434764 reaction equation
[H-].[Na+].[C:3]1([CH:9]([CH3:14])[CH2:10][C:11](=[O:13])[CH3:12])[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[CH2:15]([O:17][C:18](=[O:24])[C:19](OCC)=[O:20])[CH3:16].CC[O-].[Na+]>CCO>[CH2:15]([O:17][C:18](=[O:24])[C:19](=[O:20])[CH2:12][C:11](=[O:13])[CH2:10][CH:9]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1)[CH3:14])[CH3:16]

Participants

6

Reactant 4

HCID 7268Diethyl OxalateHCID 24758Sodium hydrideHCID 866364-Phenylpentan-2-oneHCID 2723922Sodium ethoxide

Product 1

HCID 57435095HCID 57435095, compoundYield 42.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Sodium hydride (0.1702 g, 7.09 mmol) was added slowly to a NaCl ice bath containing EtOH (2.6 mL, 2.7 M) stirring under N2. 4-Phenylpentan-2-one (55) (1.0493 g, 6.47 mmol) and diethyloxalate (0.88 mL, 6.47 mmol) were mixed together, and then added to the chilled NaOEt solution. After stirring for 5 minutes, the reaction was warmed to room temperature. After 90 min, the reaction was quenched at 0° C. with 1N HCl and extracted 2× with CH2Cl2. The combined organics were washed with H2O, dried with Na2SO4, filtered, concentrated to provide 56 (0.7230 g, 42.6%) which was used without further purification in the next step. 1H (CDCl3, 400 MHz): δ 7.34-7.16 (5H, m), 6.30 (1H, s), 4.33 (2H, q, J=7.0 Hz), 3.39-3.26 (1H, m), 2.82 (1H, dd, J=15.1, 6.8 Hz), 2.72 (1H, dd, J=15.1, 7.8 Hz), 1.36 (3H, t, J=7.0 Hz), 1.32 (3H, d, J=6.8 Hz) ppm. HPLC: 10.934 min.

Workup

  1. stirringAfter stirring for 5 minutes
  2. customthe reaction was quenched at 0° C. with 1N HCl
  3. extractionextracted 2× with CH2Cl2
  4. washThe combined organics were washed with H2O
  5. dry with materialdried with Na2SO4
  6. filtrationfiltered
  7. concentrationconcentrated

Sources & evidence

ORD record
ord-83cbf8813f504ce8b6c8acb93b192795
Source dataset
uspto-grants-2009_11
Patent number
US07615572B2

Reaction notes

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